Sehlahisoa

Fluralaner ke chefo e bolaeang likokoanyana le acaricide e sebelisoang ka molomo kapa ka holimo.

Fluralaner e thibela γ-aminobutyric acid (GABA) -gated chloride channels (GABAA receptors) le L-glutamate-gated chloride channels (GluCls).Matla a fluralaner a bapisoa le fipronil.

Ke sebolaya-dikhunkhwane sa mefuta e mengata se nang le sebolaya dikokwana-hloko se setle kgahlanong le dikgofa, matsetse, dinta, hemiptera le diptera, mme bolwetsi ba sona bo phahame ho feta kapa bo bapiswa le bo bolayang dikokonyana tse sebediswang hangata.

Tleliniki e bontša hore Fluralaner e ka fana ka tšireletso ea nako e telele ea libeke tse 12 bakeng sa lintja ho antibody ectoparasite effect.E bonolo ebile e sebetsa hantle bakeng sa liphoofolo tse ruuoang lapeng le liphoofolo tse ruuoang lapeng.

E ka leleka le ho bolaea matsetse bakeng sa lintja.E ka sebetsa kapele ho matsetse a batho ba baholo mme e tšoarelle nako e telele.E ka boela ea thibela matsetse hore a se ke a phunyeletsa mahe, kahoo a senya bophelo ba matsetse.Li-ectoparasites tsena tse tloaelehileng tsa liphoofolo tse ruuoang lapeng li monya phepo ea liphoofolo, 'me li ka boela tsa jala maloetse a mangata, a kang liboko tse chesitsoeng, lefu la Lyme, encephalitis ea morung, joalo-joalo E ke ke ea ama feela kholo le bophelo bo botle ba liphoofolo tse ruuoang lapeng, empa hape e tla tlisa likotsi tse ka bang teng bophelong ho beng ba liphoofolo.Fluralaner ha e na tšebetso ho li-receptor tsa tsamaiso ea methapo ea mammalian, kahoo e bolokehile haholo bakeng sa liphoofolo tse anyesang.

Fluralaner e batla e bola ke liphoofolo tse nyane.Mofuta oa pele oa limolek'hule o ka bang 90-100% o ntšoa ka mantle ntle le metabolites.Hoo e ka bang ha ho na renal excretion, tšireletso e babatsehang, ha ho na tšenyo ea sebete le liphio tsa liphoofolo tse nyenyane.

Ha e tsejoe hore na ke eng e hanyetsang lithethefatsi le hore na e sebetsa joang ka lithethefatsi, 'me ha e hanyetsane le chefo e bolaeang likokoanyana.Ka mor'a ho tsamaisoa ka molomo, lithethefatsi li ajoa ka ho lekana holim'a 'mele.E sebetsa lihora tse 2 ka mor'a tsamaiso ea molomo.Ka mor'a lihora tse 4, e ka bolaea bonyane 80% ea likokoanyana.Nako ea ts'ireletso e ka fihla libeke tse 12.Tšoaetso e pheta-phetoang e ka boela ea finyella phello e ntle haholo ea ho leleka likokoanyana.Ke mofuta oa lithethefatsi tsa antibody ectoparasite tse nang le polokeho e phahameng, e leng bohlokoa haholo ho sebelisoa.